The inability to fall asleep is typically caused by wondering, intrusive thoughts and stress, factors which are known to be associated with elevated neural sympathetic activity. To quiet our racing thoughts, the American Academy of Sleep Medicine recommends deep breathing exercises [1,2]. The problem is that sleep-inducing breathing exercises are highly specific, difficult to master, and require concentration to do correctly.

2breathe induces sleep by captivating the racing mind, keeping it focused on breathing via its guiding tones. The whole breathing synchronization and prolonging the exhalation process happens subliminally in a way you can’t do on your own. The tones guide the breathing via the emotional part of the brains and not the “decision-making” cognitive part of the brain, as other methods such as counting or “thinking about it” tend to do.

Furthermore, 2breathe’s core patented technology composes the guiding tones in real-time, in a way that continuously adapts to the user’s ability to be guided. Such adaptive guidance creates an optimal and personalized breathing exercise shown to play a prominent role in the beneficial effect beyond pre-recorded relaxing tones used by most breathing apps [3, 4].

Clinical Evidence

2breathe technology grew out of RESPeRATE, the world’s only non-drug medical device cleared by the FDA for lowering blood pressure and the reduction of stress. Used by hundreds of thousands of patients and is featured in the American Heart Association statement on non-pharmacological treatments of hypertension [5].

2breathe was developed after finding that RESPeRATE users reported dozing off during sessions, and over 90% of them reported improved sleep.

 

RESPeRATE clinical studies supported these reports by demonstrating positive effects on factors that play prominent role in sleeplessness, including lowering neural sympathetic activity [6, 7, 8]. More specifically, two separate randomized controlled studies reported that RESPeRATE used during the day improved sleep in different populations: Reduction in insomnia severity index in menopausal women [9], and in the severity of sleep disordered breathing in heart failure patients [10].

 

  1. Morgenthaler T, Practice parameters for the psychological and behavioral treatment of insomnia: an update. An american academy of sleep medicine report. Sleep 2006;29:1415-9
  2. Bertisch SM, Use of relaxation techniques and complementary and alternative medicine by American adults with insomnia symptoms: results from a national survey. Journal of Clinical Sleep Medicine, Vol. 8, No. 6, 2012
  3. Schein MH, Gavish B, Herz M, Rosner-Kahana D, Naveh P, Knishkowy B, Zlotnikov E, Ben-Zvi N, Melmed RN. Treating hypertension with a device that slows and regularises breathing: a randomised, double-blind controlled study. J Hum Hypertens. 2001;15:271-278.
  4. Ekman I, Kjellström B, Falk K, Norman J, Swedberg K. Impact of device-guided slow breathing on symptoms of chronic heart failure: a randomized, controlled feasibility study. Eur J Heart Fail. 2011;13:1000-1005.
  5. Brook RC et al. A Scientific Statement From the American Heart Association Beyond Medications and Diet: Alternative Approaches to Lowering Blood Pressure. Hypertension. 2013;61(6):1360-1383.
  6. Oneda B, Ortega KC, Gusmão JL, Araújo TG, Mion D Jr. Sympathetic nerve activity is decreased during device-guided slow breathing. Hypertens Res. 2010 Jul;33(7):708-712.
  7. Harada D, Asanoi H, Takagawa J, Ishise H, Ueno H, Oda Y et al. Slow and deep respiration suppresses steady-state sympathetic nerve activity in patients with chronic heart failure: from modeling to clinical application. American Journal of Physiology-Heart and Circulatory Physiology. 2014;307(8):H1159-H68.
  8. Hering D, Kucharska W, Kara T, Somers VK, Parati G, Narkiewicz K. Effects of acute and long-term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension. J Hypertens. 2013;31:739-746.
  9. Huang AJ1, Phillips S, Schembri M, Vittinghoff E, Grady D. Device-guided slow-paced respiration for menopausal hot flushes: a randomized controlled trial. Obstet Gynecol. 2015;125:1130-1138
  10. Debicka-Dabrowska D, Lisi E, Drozdz T, Styczkiewicz K, Malfatto G, Salerno S, Bednarek A, Olszanecka A, Kielbasa G, Bilo G, Czarnecka, D, Kawecka-Jaszcz K, Parati G. Usefulness of slow breathing training in chronic heart failure. Study design and intermediate results. Journal of Hypertens 2015:33 e-Supplement1; e 462